Artboard 33 Artboard 16 Artboard 18 Artboard 42 Artboard 21 Artboard 5 Artboard 45 Artboard 22 Artboard 42 Artboard 23 Artboard 17? Artboard 28 Artboard 43 Artboard 49 Artboard 47 Artboard 38 Artboard 32 Artboard 22 Artboard 5 Artboard 25 Artboard 1 Artboard 42 Artboard 11 Artboard 41 Artboard 23 Artboard 4 Artboard 9 Artboard 6 Artboard 7 Artboard 3 Artboard 12 Artboard 25 Artboard 34 Artboard 43 Artboard 44 Artboard 39 Artboard 24 Artboard 13 Artboard 24 Artboard 31 Artboard 27 Artboard 30 Artboard 36 Artboard 44 Artboard 17 Artboard 6 Artboard 27 Artboard 30 Artboard 29 Artboard 26 Artboard 2 Artboard 20 Artboard 35 Artboard 15 Artboard 14 Artboard 50 Artboard 26 Artboard 40 Artboard 21 Artboard 10 Artboard 37 Artboard 46 Artboard 8
e-book

Alexander Disease - A Guide for Patients and Families (Cód: 9925823)

Albee Messing

Morgan and Claypool Publishers (Livros Digitais)

Ooops! Este produto não está mais a venda.
Mas não se preocupe, temos uma versão atualizada para você.

Ooopss! Este produto está fora de linha, mas temos outras opções para você.
Veja nossas sugestões abaixo!

R$ 71,88

em até 2x de R$ 35,94 sem juros

Total:

Em até 1x sem juros de


Crédito:
Boleto:
Cartão Saraiva:

Total:

Em até 2x sem juros de


Alexander Disease - A Guide for Patients and Families

R$71,88

Descrição

This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord.
Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.
Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.
We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.
GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.
Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.

Características

Peso 0.00 Kg
Produto sob encomenda Sim
Marca Morgan and Claypool Publishers (Livros Digitais)
Número de Páginas 96 (aproximado)
Idioma 337
Acabamento e-book
Territorialidade Internacional
Formato Livro Digital Pdf
Gratuito Não
Proteção Drm Sim
Tamanho do Arquivo 2104
Início da Venda 14/11/2017
Código do Formato Pdf
Cód. Barras 9781615047598
Ano da Publicação 2017
AutorAlbee Messing