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Cardiotoxicity of Non-Cardiovascular Drugs (Cód: 9237369)

Minotti, Giorgio

John Wiley & Sons

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Cardiotoxicity of Non-Cardiovascular Drugs

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Descrição

Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In 'Cardiotoxicity of Non-Cardiovascular Drugs' international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies 'Cardiotoxicity of Non-Cardiovascular Drugs' is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease. Some drugs which are not aimed at treating heart diseases have nevertheless been found to have profound effects on the cardiovascular system. Cardiotoxicity is one of the major untoward effects of drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. In recent years a number of non-cardiac blockbuster drugs have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been halted prior to marketing or required labelling changes that significantly restricted their use. 'In Cardiotoxicity of Non-Cardiovascular Drugs' international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Emphasis is also paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects cellular mechanisms, molecular targets and structure-activity relationships in arrhythmias by antihistamines, psychoactive drugs and antimicrobial agents cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies 'Cardiotoxicity of Non-Cardiovascular Drugs' is an essential guide to this important area of drug development and surveillance. It will find a place on the bookshelves of basic and clinical researchers, regulators, and students interested in oncology, cardiology, pharmacology, medicinal chemistry and drug development.

Características

Peso 0.64 Kg
Produto sob encomenda Sim
Marca John Wiley & Sons
I.S.B.N. 9780470772744
Referência 011091610
Altura 23.11 cm
Largura 15.49 cm
Profundidade 2.54 cm
Número de Páginas 360
Idioma Inglês
Acabamento Capa dura
Cód. Barras 9780470772744
Ano da edição 2010
AutorMinotti, Giorgio