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Adenosine, Cardioprotection And Its Clinical Application (Cód: 6326296)

Robert M. Mentzer Jr.; Masafumi Kitakaze; James M. Downey


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Adenosine, Cardioprotection And Its Clinical Application



The immense growth in the number of articles on adenosine cardioprotection in recent years has been related in large part to the hypothesis that adenosine plays a role in ischemic preconditioning. Ischemic
preconditioning is the phenomenon in which a brief period of ischemia (and reperfusion) prior to a more prolonged occlusion reduces myocardial infarct size. This form of myocardial protection has received much interest
because ischemic preconditioning has been shown to be the most potent means of reducing infarct size in all animal models so far tested. Within the last six years, the principal focus of adenosine
cardioprotection research has centered on the role of adenosine receptors. It is currently thought that adenosine protects the ischemic heart primarily via the activation of adenosine A1 receptors
located on the cardiac myocytes. Adenosine is used clinically for terminating supraventricular tachycardia, and as a diagnostic tool in coronary imaging, and has been used postoperatively for blood pressure
control after heart surgery. There are also recent reports that adenosine may be safely tolerated and a potentially beneficial additive to cardioplegic solutions during open heart surgery in humans. There is even evidence
that ischemic preconditioning may occur in humans under various clinical situations. This volume contains chapters from contributors to the first three symposia on `Adenosine, Cardioprotection, and its Clinical
Application'. All aspects of adenosine cardioprotection and ischemic preconditioning, including potential mechanisms and clinical applications, are discussed by experts in these areas. The reader will find this book to be
an excellent source of information on these topics, as well as a guide to future experiments.


Produto sob encomenda Sim
Cód. Barras 9780792399544
Altura 23.40 cm
I.S.B.N. 9780792399544
Profundidade 1.59 cm
Referência 9780792399544
Ano da edição 1997
Idioma Inglês
Número de Páginas 260
Peso 0.45 Kg
Largura 15.60 cm
AutorRobert M. Mentzer Jr.; Masafumi Kitakaze; James M. Downey