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Excitation-Contraction Coupling And Cardiac Contractile Force (Cód: 582141)

Donald Bers

SPRINGER VERLAG POD

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Excitation-Contraction Coupling And Cardiac Contractile Force

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Descrição

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and
non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding
the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and
physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful
illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of
excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many
underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into
a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory
processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile
Force &endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the
cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Características

Produto sob encomenda Sim
Marca SPRINGER VERLAG POD
Cód. Barras 9780792371571
Altura 23.40 cm
I.S.B.N. 9780792371571
Profundidade 2.54 cm
Referência 9780792371571
Número da edição 2
Ano da edição 2001
Idioma Inglês
Número de Páginas 456
Peso 0.45 Kg
Largura 15.60 cm
AutorDonald Bers